This profile was published in www.eeeguyz.com on 24.08.09 

SAJI GEORGE

6/503, Accolade Housing Co-op Society,

Louiswadi, Murphy, Behind LIC Office

Thane West, Pin 400 064,

INDIA.

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                                                   SUMMARY

Articulate dynamic leader with diverse blend of process development, technology transfer and commercial cGMP drug manufacturing experience. Scale-up expertise in fermentation based NCE and other commercially established biomolecules. Experience in preparation of BMR,  process validation, cleaning validation and batch record maintenance.  Design and planning of various experiments from screening to process establishment for new drug discovery. Development of green chemistry through bioroute for production of Pharmaceutically important API’s. 

ACADEMIC  

1. Doctor of Philosophy (Biotechnology)
2. Master of Technology ( Biotechnology)
3. Master of Science (Life Sciences)
4. Diploma in Export Management (course work)

                                             CAREER HISTORY

                             Professional experiences

CORE COMPETENCE

Bioprocess Technology for the production of Antibiotics, Enzymes, Biopolymers (for wrinkle lift), New Chemical Entities etc.

Industrial Biotransformation using enzymes and whole cells (Hydroxy Lactam, L-chloropropionic acid, R-Malic acid etc.)

     Project Planning and Commissioning

     Project Assimilation and Technology Validation

     Indigenization of imported Technology

     Bio-combinatorial Technology by Phage Display

     New Drug Discovery from Natural Products

     Vaccine Delivery by Archaeosome Technology

     Production of Archaeal Lipids from Archaeal Bacteria

Recombinant Vaccine Production (HPV L1, gp120, Vasculo- Intestinal Peptide, Retinoblastoma etc.) 
 
 

2008  till date (1999-‘02- Group Leader, 2002-08 Senior Group Leader)

Asst. Director, Fermentation, Department of natural products,  Piramal Lifesciences Ltd, Goregaon East, Mumbai 400 063. 

Job profile: 

Planning, organizing and execution of  fermentation batches (10L to 20,000L) of different Fungal, Bacterial (recombinant) and Actinomycetes. 

NCE’s (New Chemical Entity) resource generation   for  anticancer, anti-infectives, anti-inflammatory and antidiabetic indications. 

Part of Innovation group for biotransformation for the production of different API in liaison with UK NPIL team (out sourcing) 

Extraction and purification of different metabolites (involves centrifugation, solvent extraction, filtration, concentration, column purification etc.). 

Process optimization for increased production of new molecules.

Biotransformation with whole cells and enzymes.   

Maintenance, trouble shooting and repair of pilot fermentors and associated downstream equipments. 

Planning and Budgeting. 

Library in-charge (Additional responsibility)

Public Funded Projects

      DBT project in Microbial Prospecting (Principle Investigator) 

      DBT (soft loan) Vaccine Development (co-investigator) 

April 1998 till May 1999

Post Doctoral Fellow, Department of Pathology and Laboratory Medicine, Houston Medical School, University of Texas, Houston, Texas, USA.      

Recombinant Phage display for catalytic antibody production from E.coli for HIV.

Medium throughput screening and selection of recombinants in 96 well plates.

Fermentation and purification of antibodies using Ni columns.  

1991- April 1998

Joint Manager, SPIC Pharma, Madras. 

Job profile:

Validation and indigenisation of fermentation process for Pen G production.

Optimization for Penicillin G production in fermentors.

In process control for PenG production in large fermentors (100m³).

Liaison between research and production for PenG.

Head of pilot plant for fermentation.

MEMBERSHIPS

Member, DBT Govt of India,  Microbial Prospecting

Anna University, Chennai  MTech Biotechnology Syllabus forming Committee

Anna University PhD Examiner (Dept of Applied Chemistry, CLRI, Chennai, NIO, Goa) 

Member of American Association for Advancement of Sciences. 
 

EDUCATION 

Ph.D. (Biotechnology)   June 1991

Center for Biotechnology,  Anna University, Madras, India. 

Technology of Production of Proteases from B.amyloliquefaciens and its applications.  

M Tech. (Biotechnology) 1987

Center for Biotechnology,  Anna University, Madras, India. 

Antibiotic Production by Immobilized B.polymyxa. 

M Sc. (Life Sciences) 1985

University of Kerala,Trivandrum, Kerala, India. 

Awards & Grants 

1. UGC Fellowship Anna University - 1987

2. Gold Medallist (M.Tech. Biotechnology), Anna University, Madras, India - 1987

3. GATE  Scholar -  1985

4. Kerala University Merit Scholarship during Masters program - 1982

5. Merit Certificate and Prof.K.P.Sebastian Endowment Award for the highest marks in under graduate program - 1982

6. Cash Award and Merit Certificate from TKMM College, Quilon, India for securing highest marks in higher secondary examinations - 1979 

Technology  Transfer 

International 

1.      Immobilized Metal Ion Affinity Chromatography (IMAC)  

           In UTC, France 1985 (10 months) 

1.       Beta Lactam industrial Production  in Cipan, Portugal 1992

1. Postdoctoral training in Texas towards development of immunotherapeutic drug against HIV using r-DNA technology.1998

1. Archaeosome prepration for Vaccine delivery at National Research Council, Ottawa, Canada, October 2005.

1. Dehalogenase Production from r-Ecoli for production of L-chloro Propionoc acid production

1. Diketo Lactam reduction using Yeast

1. 4-AD production using Mycobacterium

List of Publications/ Patents 

PATENTS

1. A novel antibiotics produced by a marine micro-organism.   PCT WO2007/119201A2
2. A novel anti-inflammatory derivative of Cocanamycin derived fro Antarctic Actinomycete  (PCT filed)
3. A novel antidiabetic molecule from marine Actinomycete (PCT under prepn.)

Conferences: 

1. Raju V, George S, Uma R, Amudeswari S, Krishnan MRV : Environmental safer methods of unhairing of hides and skin. TGT 90, Center for Leather Technology, Madras, India, 1990. 

2. George S, Raju V, Subramanian TV, Krishnan MRV, Jayaraman K : Production and application of bacterial proteases. CHEMCON 91, Alagappa College of Technology, Madras, India, 1991. 

Papers 

1. Prabhakaran K, George S, Ramesh KS, Srinivasan CV, Kandaswamy NR,  Sadhukhan. Enzymatic production and isolation of D-amino acid from the  corresponding 5 substituted Hydantoin. Process Biochemistry 28 : 447-452,  1993. 

2. George S, Raju V, Krishnan MRV, Subramanian TV, Jayaraman K. Production of proteases by solid substrate fermentation and its utilization in unhairing of hides and skins. Process Biochemistry 30: 457-462, 1995. 

3. George S, Chellapandian M, Sivasankar B, Sundaram P.V., & Jayaraman K. Flow rate dependent kinetics of urease immobilized on to diverse matrices. Bioprocess Engineering, 15 : 6, 311-316, 1996. 

4. George S, Sadhukhan AK. A simple and economically viable medium for the growth of A.radiabactor for the production of D-amino acid. World Journal of Microbiology and Biotechnology, 12 : 6, 657-659, 1996. 

5. George S, Sivasankar B, Chellapandian M, & Jayaraman K. A new coupling method to treat Urea fertilizer effluent Bioprocess Engineering  16: 2, 83-85, 1997 . 

6. George S, Sivasankar B, Jayaraman K, & Vijayalakshmi M.A. Production of methionine rich fraction from chickpea protein hydrolysate using immobilized metal ion affinity chromatography. Process Biochemistry  32, 5, 401-404, 1997.  

1. George S, Raju V, & Jayaraman K. Comparative study on protease production by solid substrate and submerged fermentation Bioprocess Engineering, 16,6 381, 1997.
2. Paul, S, Karle, S and S. George. Phosphonate ester and catalytic antibodies. J. Biological chemistry, vol 276, No 30, 28314-20, 2001

Personal information 

Nationality: Indian

Date of Birth: July 20, 1962

Marital Status: Married

Languages known: English, Hindi, Malayalam & Tamil. 

Telephone and E mail for correspondence:

91-22-25837986 (res).

Work:

91-22-3081 8000 (board)

91-22-3081 8837 (Direct)

9930454970(self)

georges1@vsnl.com

sgeorge@nicholaspiramal.co.in

Reference

Dr. M.D. Nair

Consultant To Pharmaceutical Industry

            A-11, Sagarika, 15, 3rd Seaward Road

            Valmiki Nagar, Chennai 600041, India

             Phone: +91-44-24901137/55853548  

             Email:  mdnair@vsnl.com