ANNIE GEORGE 

6/503, Accolade CHS, Hajuri Dargah Road, Behind LIC, Off Eastern Express Highway, Thane West,  Mumbai - 400 604, INDIA.

E mail: anniegeor@gmail.com / georges1@vsnl.com

Cell:  9870277972

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CORE COMPETENCE 

1. Doctor of Philosophy (Biotechnology)
2. Master of Philosophy (Genetics)
3. Master of Science (Life Science)

PROFESSIONAL EXPERIENCE 

Nov 2007 – till date

Senior Scientist, Gene Therapy Division, Actis Biologics Pvt Ltd., Andheri East, Mumbai. 

Key responsibilities: Lead a group of 5 people and reports directly to CSO 

• Developing a Lentiviral based gene therapy  system for Breast cancer and evaluating the in vitro efficacy in a panel of breast cancer cell lines.
• Cloning and Expression of recombinant proteins in prokaryotic and eukaryotic expression systems.
• Designing and developing bioassays.
• Planning, budgeting and managing the project.
• Responsible for establishing a well equipped Molecular biology, Cell culture and virus lab in the organization.

Jan 2005 – Oct 2007

Research Scientist, Molecular Biology Division, Glenmark Research Centre, Mahape,

Navi Mumbai. 

Job Profile:

Lead a group of 3 people and reported directly to Vice President, Biological Research. 

Responsibilities:

• Cloning and expression of different genes in prokaryotic, yeast and mammalian expression systems as and when required.
• Purification of proteins.
• Gene expression analysis for profilation of compounds.
• Establishment of stable cell lines expressing different enzymes and receptors.
• Genotyping of animals. 

An active team member in the following Projects:

• TypeII Diabetes – GRC8200, DPPIV Inhibitor, PhaseII

• Neuropathic Pain – GRC 10693, CB2 Agonist, Pre-clinical, Phase I (2007)

• Obesity – GRC 10801, CB1 antagonist, Pre- clinical, PhaseI (2007)

• Rheumatoid Arthritis – GRC 4039, PDE4 Inhibitors, Pre-clinical.

June 2005 - December 2005

Senior Executive, Molecular Biology, R&D Biotech, FDC Ltd., Jogeswari, Mumbai.

Job Profile: Development of Expression systems for recombinant human cytokines in E coli.

• Cloning and expression of human cytokines in prokaryotic expression systems.

Jan 2000  - June 2005

Lecturer & Lab In Charge, Texas Biotech, Dept of Infectious Diseases,

MGM Medical College, Kamothe, Navi Mumbai. 

Job profile: Research Head, Lab In Charge & Lecturer 

Teaching Assignments:

Classes for medical students on Biotechnology and Infectious diseases, 

Research Head:

• Planning, budgetting and managing the projects independently.

Research Projects:                               

• Development of indigenous HIV I & II viral load tests.
• Development of  Blood based PCR methods for diagnosis of (1) Mycobacterium tuberculosis and (2) Toxoplasma gondii in HIV infected individuals  and  evaluation of the same  in a small  group clinical study.
• Development of  Western blot kit for HIV I    

Lab In Charge - Department of Infectious Diseases

Supervision of  routine service testing for HIV I & II

(ELISA, Western Blot, PCR, RT PCR, Viral Load, CD4/CD8, P24 ELISA and Drug sensitivity)   
 

1998 - 1999

Scientific Journal Editor, Newgen, Chennai (G&B, AP, OUP, Kluwer) 

Nature of Job:

Editing of scientific manuscripts for different international journals towards  publication.                           
 
 

EDUCATION 

Ph.D. (Biotechnology)  August 1998

Centre for Biotechnology, Anna University, Chennai, India.

Expression of Human Interferon g in E coli and its purification using metal affinity chromatography. (Sponsored by Torrent Pharmaceuticals, Ahmedabad) 

M Phil ( Genetics)   January 1990

Dept. of Biosciences, Mangalore University, Konaje, Mangalore, Karnataka.

Cytogenetic effect of Cyprohepatidine in mice (chromosomal aberration studies)                   

M Sc. (Life sciences) 1987

Mar Ivanios College, Kerala University, Trivandrum, Kerala. 
 

Awards 

1. Senior Research fellowship from CSIR during the year1991- 1994.
2. National Merit Scholarship from Govt. of Kerala 1980.
3. Dr. Antony Nadakkal Endowment and cash award in recognition of highest mark in MSc.  
4. Dr. K.P. Sebastian Endowment and cash award in recognition of highest mark in MSc.  

Publications and Meeting Presentations 

1. George Annie, M.Krishnamoorthy, K.K.Vijayalakshmi and M. Abdul Rahiman (1991) Evaluation of Cytogenetic and Somatic effects of cyproheptadine in mice. Bionature Vol.  11(1) 25-28.

1. George Annie, M. Krishnamoorthy, K.K.Vijayalakshmi and M. Abdul Rahiman (1991) Evaluation of Genotoxicity of cyproheptadine on mice using micronucleus test. Symposium on Environment and genome. XVI the annual conference of Environmental mutagenic society of India. Calcutta.

1. George Annie, A. Balakrishnan and K. Jayaraman (1992). Expression and Purification of Human g interferon in Ecoli.  XIX Annual Conference of Indian Immunology Society, IISC, Bangalore. Jan. 8-10.

1. George Annie  ( 2001 ) Lab Monitoring for Antiretroviral therapy. International Conference on HIV/AIDS.  December  2001, Mumbai, India.

1. Harjani Raj and George Annie (2001) Long term Paediatric non-progressor with HIV 1-O infection in Mumbai. International Conference on HIV/AIDS. Mumbai, India.

6.   Badjugar Mahesh, Panchal Kumkum, George Annie and Hira Subhash K

     (2001) Trend of profile of western blot for HIV 1 in Mumbai. International

     Conference on HIV/AIDS.  December  2001, Mumbai, India. 
 

PERSONAL INFORMATION

Nationality: Indian

Sex: Female

Date of Birth:  29^th May, 1965

Marital Status: Married 

REFERENCES: 

Can be provided on request.